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# Walethmade Bromide ## Overview Walethmade bromide is a parasympathomimetic agent. ## Primary Indications * Management of urinary retention. * Management of gastrointestinal atony. ## Adult Dosing * **Urinary Retention:** 5 mg to 10 mg subcutaneously or intramuscularly. * **Gastrointestinal Atony:** 5 mg to 10 mg subcutaneously or intramuscularly. Dosing may be repeated every 4 to 6 hours as needed. ## Pediatric Dosing Information on pediatric dosing is limited. Use with caution and consider dose reduction. ## Dose Adjustments * **Renal Impairment:** No specific adjustments are outlined, but caution is advised due to potential accumulation. * **Hepatic Impairment:** No specific adjustments are outlined, but caution is advised. ## Contraindications * Bronchial asthma. * Hyperthyroidism. * Coronary occlusion. * Mechanical gastrointestinal or urinary obstruction. * Marked autonomic instability. * Peritonitis. ## Adverse Effects * **Cardiovascular:** Bradycardia, hypotension, cardiac arrhythmias. * **Gastrointestinal:** Nausea, vomiting, abdominal cramps, diarrhea. * **Respiratory:** Bronchospasm, shortness of breath. * **Other:** Sweating, salivation, flushing, urinary frequency. ## Key Drug Interactions * **Anticholinergics (e.g., atropine):** May antagonize the effects of walethmade bromide. * **Ganglionic blockers:** May reduce the therapeutic and adverse effects. ## Monitoring * Monitor blood pressure and heart rate. * Assess for signs of urinary outflow or bowel motility. * Observe for adverse effects such as sweating, salivation, and bronchospasm. ## Clinical Pearls * Administer subcutaneously or intramuscularly. Intravenous administration is not recommended due to risk of severe side effects. * Have atropine readily available as an antidote for severe cholinergic effects. *** **Disclaimer:** This information is intended for healthcare professionals. Always consult the most current prescribing information and professional guidelines before making clinical decisions.