Tus%252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252520qd

# Tus%252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252520qd (Guaifenesin) ## Overview Guaifenesin is an expectorant that increases the volume and reduces the viscosity of secretions in the trachea and bronchi, facilitating their removal by coughing. ## Primary Indications Symptomatic relief of cough associated with respiratory tract infections. ## Adult Dosing * **Immediate-release:** 200 mg to 400 mg orally every 4 hours as needed. * **Extended-release:** 600 mg to 1200 mg orally every 12 hours as needed. Maximum dose is 2400 mg/day. ## Pediatric Dosing Dosing varies by age and product formulation. Always refer to specific product labeling for pediatric dosing recommendations. Generally: * **Children 6 to <12 years:** 100 mg to 200 mg orally every 4 hours as needed. Do not exceed 1200 mg/day. * **Children 2 to <6 years:** Dosing should be based on specific product recommendations and physician guidance. * **Children <2 years:** Safety and efficacy not established. Use with caution and under medical supervision. ## Dose Adjustments No dose adjustment is typically required for renal or hepatic impairment, but caution is advised in severe disease. ## Contraindications Hypersensitivity to guaifenesin. ## Adverse Effects Generally well-tolerated. Common adverse effects include nausea, vomiting, and stomach upset. Dizziness and headache may also occur. ## Key Drug Interactions No significant drug interactions are commonly reported. ## Monitoring Monitor for effectiveness in thinning mucus and easing cough. Assess for adverse effects. ## Clinical Pearls * Adequate fluid intake is important to help thin mucus. * Guaifenesin is often combined with other ingredients (e.g., dextromethorphan, decongestants, antihistamines) in combination cold and cough products. * Its efficacy for chronic cough has not been definitively established. *** **Disclaimer:** This information is intended for healthcare professionals. Always consult the most current prescribing information and relevant guidelines for definitive recommendations. Patient-specific factors should always be considered.