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# TUSQ ## Overview TUSQ is a combination medication containing Tussov (tussolamine) and Qudeo (qudeon), a mucolytic and expectorant. Tussov is thought to act centrally on the cough center, while Qudeo may reduce mucus viscosity. ## Primary Indications * Symptomatic relief of cough associated with excessive bronchial secretions. ## Adult Dosing * **Typical Dose:** 10 mL every 6-8 hours as needed. * **Maximum Dose:** Not explicitly defined, but generally avoid exceeding 4 doses in 24 hours. ## Pediatric Dosing * **Children 6-12 years:** 5 mL every 8 hours as needed. * **Children under 6 years:** Safety and efficacy not established. Consult with a pediatrician. ## Dose Adjustments * **Renal Impairment:** No specific dose adjustments are established. Use with caution and monitor for adverse effects. * **Hepatic Impairment:** No specific dose adjustments are established. Use with caution and monitor for adverse effects. ## Contraindications * Hypersensitivity to Tussov, Qudeo, or any component of the formulation. * Severe respiratory depression. * Concurrent use with MAO inhibitors. ## Adverse Effects * **Common:** Drowsiness, dizziness, dry mouth, nausea, vomiting, constipation. * **Less Common:** Confusion, respiratory depression (especially with higher doses or in susceptible individuals), paradoxical bronchospasm. ## Key Drug Interactions * **CNS Depressants (e.g., benzodiazepines, opioids, alcohol):** Increased risk of sedation and respiratory depression. * **MAO Inhibitors:** Potentially life-threatening hypertensive crisis or serotonin syndrome. Avoid concurrent use and for at least 14 days after discontinuing MAO inhibitors. * **Other Anticholinergic Agents:** Additive anticholinergic effects (e.g., dry mouth, constipation, urinary retention). ## Monitoring * Monitor for effectiveness of cough suppression and clearance of secretions. * Observe for signs of drowsiness, dizziness, and respiratory depression. * Assess for gastrointestinal side effects such as constipation. ## Clinical Pearls * TUSQ may cause significant drowsiness; advise patients to avoid driving or operating heavy machinery until they know how the medication affects them. * Adequate hydration is important to help thin bronchial secretions. * If cough persists beyond 7 days or is accompanied by fever, rash, or persistent headache, re-evaluate the patient. --- ***Disclaimer:** This information is intended for healthcare professionals. It is essential to consult the most current prescribing information and relevant clinical guidelines for definitive guidance. Dosing and safety may vary based on individual patient factors and local protocols.*