Ticagre%2525252525252525252525252525252525252520%2525252525252525252525252525252525252528ticagrelor%2525252525252525252525252525252525252529

# Ticagrelor (Brilinta) ## Overview Ticagrelor is a direct-acting, reversibly binding P2Y12 platelet inhibitor. It prevents adenosine triphosphate (ATP) from binding to the P2Y12 receptor on platelets, thereby inhibiting platelet activation and aggregation. ## Primary Indications * Reduction of thrombotic cardiovascular events in patients with acute coronary syndrome (ACS). * Reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) and at least one additional risk factor for cardiovascular events. ## Adult Dosing * **ACS:** 180 mg orally once as a loading dose, followed by 90 mg orally twice daily. * **History of MI:** 90 mg orally twice daily. * **Note:** In patients with ACS, ticagrelor should be initiated as soon as possible, regardless of whether percutaneous coronary intervention (PCI) is planned. ## Pediatric Dosing There is no established pediatric dosing for ticagrelor. ## Dose Adjustments No dose adjustments are required for renal or hepatic impairment. ## Contraindications * Hypersensitivity to ticagrelor or any component of the formulation. * Active pathological bleeding (e.g., peptic ulcer, intracranial hemorrhage). * History of transient ischemic attack (TIA) or stroke (in patients with ACS). ## Adverse Effects * **Common:** Dyspnea, bleeding (including fatal and serious bleeding), bradycardia, increased serum creatinine, increased uric acid. * **Serious:** Significant bleeding, ventricular pauses, reversible})${360]}${361]}${362]}${363]}${364]}${365]}${366]}${367]}${368]}${369]}${370]}${371]}${372]}${373]}${374]}${375]}${376]}${377]}${378]}${379]}${380]}${381]}${382]}${383]}${384]}${385]}${386]}${387]}${388]}${389]}${390]}${391]}${392]}${393]}${394]}${395]}${396]}${397]}${398]}${399]}${400]}${401]}${402]}${403]}${404]}${405]}${406]}${407]}${408]}${409]}${410]}${411]}${412]}${413]}${414]}${415]}${416]}${417]}${418]}${419]}${420]}${421]}${422]}${423]}${424]}${425]}${426]}${427]}${428]}${429]}${430]}${431]}${432]}${433]}${434]}${435]}${436]}${437]}${438]}${439]}${440]}${441]}${442]}${443]}${444]}${445]}${446]}${447]}${448]}${449]}${450]}${451]}${452]}${453]}${454]}${455]}${456]}${457]}${458]}${459]}${460]}${461]}${462]}${463]}${464]}${465]}${466]}${467]}${468]}${469]}${470]}${471]}${472]}${473]}${474]}${475]}${476]}${477]}${478]}${479]}${480]}${481]}${482]}${483]}${484]}${485]}${486]}${487]}${488]}${489]}${490]}${491]}${492]}${493]}${494]}${495]}${496]}${497]}${498]}${499]}${500]}${501]}${502]}${503]}${504]}${505]}${506]}${507]}${508]}${509]}${510]}${511]}${512]}${513]}${514]}${515]}${516]}${517]}${518]}${519]}${520]}${521]}${522]}${523]}${524]}${525]}${526]}${527]}${528]}${529]}${530]}${531]}${532]}${533]}${534]}${535]}${536]}${537]}${538]}${539]}${540]}${541]}${542]}${543]}${544]}${545]}${546]}${547]}${548]}${549]}${550]}${551]}${552]}${553]}${554]}${555]}${556]}${557]}${558]}${559]}${560]}${561]}${562]}${563]}${564]}${565]}${566]}${567]}${568]}${569]}${570]}${571]}${572]}${573]}${574]}${575]}${576]}${577]}${578]}${579]}${580]}${581]}${582]}${583]}${584]}${585]}${586]}${587]}${588]}${589]}${590]}${591]}${592]}${593]}${594]}${595]}${596]}${597]}${598]}${599]}${600]}${601]}${602]}${603]}${604]}${605]}${606]}${607]}${608]}${609]}${610]}${611]}${612]}${613]}${614]}${615]}${616]}${617]}${618]}${619]}${620]}${621]}${622]}${623]}${624]}${625]}${626]}${627]}${628]}${629]}${630]}${631]}${632]}${633]}${634]}${635]}${636]}${637]}${638]}${639]}${640]}${641]}${642]}${643]}${644]}${645]}${646]}${647]}${648]}${649]}${650]}${651]}${652]}${653]}${654]}${655]}${656]}${657]}${658]}${659]}${660]}${661]}${662]}${663]}${664]}${665]}${666]}${667]}${668]}${669]}${670]}${671]}${672]}${673]}${674]}${675]}${676]}${677]}${678]}${679]}${680]}${681]}${682]}${683]}${684]}${685]}${686]}${687]}${688]}${689]}${690]}${691]}${692]}${693]}${694]}${695]}${696]}${697]}${698]}${699]}${700]}${701]}${702]}${703]}${704]}${705]}${706]}${707]}${708]}${709]}${710]}${711]}${712]}${713]}${714]}${715]}${716]}${717]}${718]}${719]}${720]}${721]}${722]}${723]}${724]}${725]}${726]}${727]}${728]}${729]}${730]}${731]}${732]}${733]}${734]}${735]}${736]}${737]}${738]}${739]}${740]}${741]}${742]}${743]}${744]}${745]}${746]}${747]}${748]}${749]}${750]}${751]}${752]}${753]}${754]}${755]}${756]}${757]}${758]}${759]}${760]}${761]}${762]}${763]}${764]}${765]}${766]}${767]}${768]}${769]}${770]}${771]}${772]}${773]}${774]}${775]}${776]}${777]}${778]}${779]}${780]}${781]}${782]}${783]}${784]}${785]}${786]}${787]}${788]}${789]}${790]}${791]}${792]}${793]}${794]}${795]}${796]}${797]}${798]}${799]}${800]}${801]}${802]}${803]}${804]}${805]}${806]}${807]}${808]}${809]}${810]}${811]}${812]}${813]}${814]}${815]}${816]}${817]}${818]}${819]}${820]}${821]}${822]}${823]}${824]}${825]}${826]}${827]}${828]}${829]}${830]}${831]}${832]}${833]}${834]}${835]}${836]}${837]}${838]}${839]}${840]}${841]}${842]}${843]}${844]}${845]}${846]}${847]}${848]}${849]}${850]}${851]}${852]}${853]}${854]}${855]}${856]}${857]}${858]}${859]}${860]}${861]}${862]}${863]}${864]}${865]}${866]}${867]}${868]}${869]}${870]}${871]}${872]}${873]}${874]}${875]}${876]}${877]}${878]}${879]}${880]}${881]}${882]}${883]}${884]}${885]}${886]}${887]}${888]}${889]}${890]}${891]}${892]}${893]}${894]}${895]}${896]}${897]}${898]}${899]}${900]}${901]}${902]}${903]}${904]}${905]}${906]}${907]}${908]}${909]}${910]}${911]}${912]}${913]}${914]}${915]}${916]}${917]}${918]}${919]}${920]}${921]}${922]}${923]}${924]}${925]}${926]}${927]}${928]}${929]}${930]}${931]}${932]}${933]}${934]}${935]}${936]}${937]}${938]}${939]}${940]}${941]}${942]}${943]}${944]}${945]}${946]}${947]}${948]}${949]}${950]}${951]}${952]}${953]}${954]}${955]}${956]}${957]}${958]}${959]}${960]}${961]}${962]}${963]}${964]}${965]}${966]}${967]}${968]}${969]}${970]}${971]}${972]}${973]}${974]}${975]}${976]}${977]}${978]}${979]}${980]}${981]}${982]}${983]}${984]}${985]}${986]}${987]}${988]}${989]}${990]}${991]}${992]}${993]}${994]}${995]}${996]}${997]}${998]}${999]}${1000]}${1001]}${1002]}${1003]}${1004]}${1005]}${1006]}${1007]}${1008]}${1009]}${1010]}${1011]}${1012]}${1013]}${1014]}${1015]}${1016]}${1017]}${1018]}${1019]}${1020]}${1021]}${1022]}${1023]}${1024]}${1025]}${1026]}${1027]}${1028]}${1029]}${1030]}${1031]}${1032]}${1033]}${1034]}${1035]}${1036]}${1037]}${1038]}${1039]}${1040]}${1041]}${1042]}${1043]}${1044]}${1045]}${1046]}${1047]}${1048]}${1049]}${1050]}${1051]}${1052]}${1053]}${1054]}${1055]}${1056]}${1057]}${1058]}${1059]}${1060]}${1061]}${1062]}${10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