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# Tabvoihep
## Overview
Tabvoihep is a brand name for Hepatitis B Immune Globulin (Human). It is a sterile solution of antibodies (specifically IgG) pooled from the plasma of human donors who have high titers of antibodies to the Hepatitis B surface antigen (anti-HBs). It is used for prophylaxis against Hepatitis B virus (HBV) infection.
## Primary Indications
* Post-exposure prophylaxis to Hepatitis B infection following percutaneous or permucosal exposure.
* Prophylaxis in neonates born to HBsAg-positive mothers.
## Adult Dosing
* **Post-exposure prophylaxis:** Administer 0.06 mL/kg intramuscularly (IM) as a single dose. The dose should not exceed 5 mL.
* **Neonatal prophylaxis:** Administer 0.5 mL IM as a single dose to the neonate.
## Pediatric Dosing
* **Neonatal prophylaxis:** Administer 0.5 mL IM as a single dose to the neonate.
## Dose Adjustments
No specific dose adjustments are typically required for renal or hepatic impairment.
## Contraindications
* Individuals with a history of severe allergic reaction to immune globulin preparations or any component of the formulation.
* IgA deficiency with documented anti-IgA antibodies and a history of hypersensitivity.
## Adverse Effects
* **Common:** Pain, redness, swelling, or itching at the injection site. Headache, fatigue, nausea, dizziness.
* **Serious (rare):** Anaphylaxis, aseptic meningitis syndrome (AMS), thromboembolic events, renal dysfunction/acute renal failure, hemolytic anemia, transfusion-related acute lung injury (TRALI).
## Key Drug Interactions
* **Live virus vaccines:** Live virus vaccines (e.g., measles, mumps, rubella, varicella) should be deferred for at least 3 months after administration of Hepatitis B Immune Globulin.
## Monitoring
* Monitor for signs and symptoms of allergic or hypersensitivity reactions.
* Monitor for signs of thromboembolic events.
* Monitor renal function if risk factors for renal dysfunction are present.
## Clinical Pearls
* Hepatitis B Immune Globulin should be administered as soon as possible after exposure, preferably within 7 days for percutaneous exposure.
* For neonates born to HBsAg-positive mothers, the recommended schedule is Hepatitis B Immune Globulin (0.5 mL IM) and Hepatitis B vaccine (0.5 mL IM) within 12 hours of birth.
* This product is for IM use only. Do not administer intravenously.
* If a patient has received Hepatitis B Immune Globulin, it can interfere with the immune response to live virus vaccines.
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**Disclaimer:** This information is intended for healthcare professionals and does not replace current prescribing information. Always verify the latest product information and consult with relevant resources before making clinical decisions.
