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# Tabvoihep ## Overview Tabvoihep is a brand name for hepatitis B immune globulin (HBIG) injection. It is a sterile solution of antibodies (immunoglobulins) from human plasma that provides passive immunity against the hepatitis B virus (HBV). ## Primary Indications * **Post-exposure prophylaxis for HBV:** To prevent HBV infection following exposure, including: * Perinatal exposure of infants born to HBsAg-positive mothers. * Needlestick or sharps exposure in susceptible individuals. * Sexual exposure to an HBsAg-positive individual in susceptible individuals. * Hemodialysis patients. * Infants born to HBsAg-positive mothers who have not received hepatitis B vaccine and HBIG at birth. ## Adult Dosing * **Post-exposure prophylaxis (percutaneous exposure):** 0.06 mL/kg IM as a single dose, administered as soon as possible and preferably within 7 days of exposure. * **Post-exposure prophylaxis (sexual exposure):** 0.06 mL/kg IM as a single dose, administered as soon as possible and preferably within 14 days of sexual exposure. * **Perinatal prophylaxis (infants born to HBsAg-positive mothers):** 0.5 mL (10 mcg/kg) IM within 12 hours of birth. This is typically given concurrently with the first dose of hepatitis B vaccine. ## Pediatric Dosing * **Perinatal prophylaxis (infants born to HBsAg-positive mothers):** 0.5 mL (10 mcg/kg) IM within 12 hours of birth. This is typically given concurrently with the first dose of hepatitis B vaccine. * **Post-exposure prophylaxis (percutaneous or sexual exposure):** 0.06 mL/kg IM as a single dose, administered as soon as possible. ## Dose Adjustments No dose adjustments are typically required for renal or hepatic impairment. The dose is weight-based. ## Contraindications * Known severe allergic reaction (anaphylaxis) to human immunoglobulin preparations or any component of the formulation. * History of prior hypersensitivity to immune globulins. ## Adverse Effects * **Common:** Pain, redness, swelling at the injection site; headache, fatigue, fever, nausea. * **Serious (rare):** Anaphylaxis, aseptic meningitis syndrome (AMS), thromboembolic events, hemolytic anemia, renal dysfunction. ## Key Drug Interactions * **Live attenuated virus vaccines:** Do not administer live vaccines within 3 months of HBIG administration, as it may interfere with the immune response. Wait at least 4 months to administer live vaccines. * **Hepatitis B vaccine:** HBIG can be administered concurrently with the hepatitis B vaccine at separate injection sites. ## Monitoring * Monitor for signs of allergic reaction, including anaphylaxis. * Monitor for local injection site reactions. * Monitor for signs and symptoms of HBV infection. ## Clinical Pearls * HBIG provides temporary passive immunity. Vaccination with the hepatitis B vaccine series is still recommended for long-term active immunity, even after HBIG administration for post-exposure prophylaxis. * For neonates born to HBsAg-positive mothers, the combination of HBIG and the hepatitis B vaccine administered within 12 hours of birth is the standard of care. * Ensure adequate hydration when administering HBIG. *** *This information is intended for healthcare professionals. Always consult the most current prescribing information and relevant clinical guidelines before making treatment decisions.*