Tab%25252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252520voihep

# Tabuvolhep (Tabuvolhep) ## Overview Tabuvolhep is an antiviral medication used in the treatment of chronic hepatitis B virus (HBV) infection. ## Primary Indications Chronic Hepatitis B Virus (HBV) Infection. ## Adult Dosing The recommended dose is 10 mg orally once daily. ## Pediatric Dosing Dosing in pediatric patients has not been established. ## Dose Adjustments No dose adjustment is required for patients with mild to moderate renal impairment (creatinine clearance [CrCl] ≥ 30 mL/min). Data for severe renal impairment are limited. No dose adjustment is typically needed for hepatic impairment, but caution is advised in patients with decompensated cirrhosis. ## Contraindications Hypersensitivity to tabuvolhep or any excipient. ## Adverse Effects Common adverse effects include headache, nausea, and fatigue. Less common but serious adverse effects can include lactic acidosis, severe hepatomegaly with steatosis, and emergence of lamivudine-resistant HBV. ## Key Drug Interactions No significant drug interactions have been established. ## Monitoring Monitor liver function tests (ALT, AST, bilirubin) regularly. Assess HBV DNA levels periodically. Monitor for signs and symptoms of lactic acidosis or liver decompensation. ## Clinical Pearls Tabuvolhep should be taken with or without food. Discontinuation of therapy, especially in patients with co-infection of HBV and HIV, may lead to severe HBV exacerbations. *** **Disclaimer:** This information is intended for clinical professionals and does not replace the need to consult the most current prescribing information and institutional guidelines. Always verify current drug information before making clinical decisions.