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# Tabravihiep (Tavaborole) ## Overview Tavaborole is an oxaborole antifungal agent that inhibits fungal protein synthesis by inhibiting leucyl-tRNA synthetase. It is formulated as a 5% topical solution for the treatment of onychomycosis. ## Primary Indications Onychomycosis of the toenails due to *Trichophyton rubrum* or *Trichophyton mentagrophytes*. ## Adult Dosing Apply to the affected toenail(s) once daily. Use the provided applicator to cover the entire nail plate and under the free edge of the nail. ## Pediatric Dosing Safety and efficacy have not been established in patients younger than 6 years. For patients ≥6 years, dosing is the same as adults (apply once daily). ## Dose Adjustments No specific dosage adjustments are required for renal or hepatic impairment due to minimal systemic absorption. ## Contraindications Hypersensitivity to tavaborole or any component of the formulation. ## Adverse Effects - Application site exfoliation - Ingrown toenail (onychocryptosis) - Application site erythema - Application site dermatitis ## Key Drug Interactions None significant due to low systemic absorption and lack of systemic metabolic pathways when applied topically. ## Monitoring - Monitor for signs of local irritation or worsening of the infection. - Clinical efficacy should be evaluated after 48 weeks of treatment. ## Clinical Pearls - Treatment requires up to 48 weeks of once-daily application. - The nail must be clean and dry prior to application. - Avoid contact with eyes, mouth, or vagina. - If no clinical improvement is observed after 48 weeks, consider alternative treatments. - Efficacy is generally lower in distal subungual onychomycosis with significant involvement of the nail matrix (lunula). *** **Educational Disclaimer:** This information is for educational purposes only and does not constitute medical advice. Always verify current prescribing information, package inserts, and institutional protocols before prescribing or administering any medication.