Please check your internet connection and try again.
# Sompraz HP (Rabeprazole Sodium)
## Overview
Rabeprazole is a proton pump inhibitor (PPI) that suppresses gastric acid secretion.
## Primary Indications
* Healing of erosive esophagitis
* Maintenance of healing of erosive esophagitis
* Symptomatic gastroesophageal reflux disease (GERD)
* H. pylori eradication (in combination with antibiotics)
* Prevention of NSAID-induced gastric ulcers
## Adult Dosing
* **Healing of erosive esophagitis:** 20 mg orally once daily for 4 to 8 weeks.
* **Maintenance of healing of erosive esophagitis:** 10 mg to 20 mg orally once daily. The dose should be individualized.
* **Symptomatic GERD:** 20 mg orally once daily for 4 weeks. If symptoms do not resolve, consider an additional 4 weeks.
* **H. pylori eradication:** 20 mg orally twice daily for 7 days in combination with appropriate antibiotics (e.g., amoxicillin and clarithromycin).
* **Prevention of NSAID-induced gastric ulcers:** 10 mg or 20 mg orally once daily.
## Pediatric Dosing
* **Symptomatic GERD:** Safety and efficacy not established in pediatric patients.
* **Erosive esophagitis:** Safety and efficacy not established in pediatric patients.
## Dose Adjustments
No dose adjustment is generally required for patients with renal impairment or hepatic impairment. However, caution and close monitoring may be warranted in severe hepatic impairment.
## Contraindications
* Known hypersensitivity to rabeprazole, substituted benzimidazoles, or any component of the formulation.
## Adverse Effects
Common adverse effects include headache, diarrhea, abdominal pain, nausea, vomiting, and dizziness.
## Key Drug Interactions
* **Drugs dependent on gastric pH for absorption:** PPIs can decrease gastric pH, potentially affecting the absorption of drugs like ketoconazole, itraconazole, and certain HIV protease inhibitors.
* **Methotrexate:** PPIs may increase and prolong serum levels of methotrexate, potentially leading to toxicity.
* **CYP2C19 substrates:** Rabeprazole is a moderate inhibitor of CYP2C19. Concurrent use with clopidogrel may lead to decreased exposure to clopidogrel's active metabolite, potentially reducing its antiplatelet effect.
## Monitoring
* Monitor for symptomatic improvement.
* Monitor for signs and symptoms of H. pylori infection if used for eradication.
* Consider monitoring electrolytes (e.g., magnesium) with long-term PPI therapy.
## Clinical Pearls
* Rabeprazole may be taken with or without food.
* For H. pylori eradication, ensure completion of the full antibiotic course.
* Long-term use of PPIs has been associated with an increased risk of bone fractures, Clostridium difficile-associated diarrhea, and vitamin B12 deficiency.
***
**Disclaimer:** This information is intended for healthcare professionals. It is essential to consult the most current prescribing information and relevant clinical guidelines for complete details and to verify dosing and safety before patient use.
