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## Oxymetazoline Nasal Spray ### Overview Oxymetazoline is an alpha-adrenergic agonist that acts as a topical vasoconstrictor. It is available as a nasal spray. ### Primary Indications * Nasal congestion due to the common cold, hay fever, or other upper respiratory allergies. ### Adult Dosing * **Nasal Spray (0.05%):** 2-3 sprays in each nostril every 10-12 hours as needed. * **Maximum:** Do not exceed 2 doses in a 24-hour period. ### Pediatric Dosing * **Children 6 to under 12 years:** 2-3 sprays in each nostril every 10-12 hours as needed. * **Children under 6 years:** Use is not recommended. Consult a pediatrician. ### Dose Adjustments No specific dose adjustments are routinely required for hepatic or renal impairment. ### Contraindications * Hypersensitivity to oxymetazoline or any component of the formulation. * Patients with narrow-angle glaucoma. * Patients on monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOIs. ### Adverse Effects * **Common:** Nasal burning, stinging, dryness, sneezing, temporary blurred vision, headache, increased blood pressure. * **Serious:** Rebound congestion (rhinitis medicamentosa) with prolonged or excessive use. ### Key Drug Interactions * **MAO Inhibitors:** Concomitant use can cause severe hypertension. * **Tricyclic Antidepressants (TCAs):** May potentiate the pressor effects of oxymetazoline. * **Beta-blockers:** May lead to an increased risk of hypertension. ### Monitoring * Monitor for rebound congestion with prolonged use. * Monitor blood pressure, especially in patients with pre-existing hypertension or cardiovascular disease. ### Clinical Pearls * Limit use to a maximum of 3 consecutive days to prevent rebound congestion. * If symptoms persist, discontinue use and consult a healthcare provider. * Administer upright to minimize swallowing. *** *Disclaimer: This information is intended for clinical use and does not replace professional medical advice. Always consult the official prescribing information and your healthcare provider to ensure patient safety and appropriate treatment.*