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# Oxymetazoline Nasal Spray ## Overview Oxymetazoline is an alpha-adrenergic agonist that acts as a topical vasoconstrictor. ## Primary Indications Temporary relief of nasal congestion due to the common cold, hay fever, or other upper respiratory allergies. ## Adult Dosing * **Nasal Spray:** 2 sprays in each nostril every 10-12 hours as needed. * **Maximum Daily Dose:** Do not exceed 2 doses in a 24-hour period. ## Pediatric Dosing * **Children 6 to under 12 years:** 1 to 2 sprays in each nostril every 10-12 hours as needed. * **Children under 6 years:** Not recommended without physician advice. ## Dose Adjustments No specific dose adjustments are typically required for renal or hepatic impairment. ## Contraindications * Hypersensitivity to oxymetazoline or any component of the formulation. * Patients currently taking or who have taken MAO inhibitors within the last 14 days. ## Adverse Effects * **Common:** Nasal discomfort, burning, stinging, sneezing, increased nasal discharge. Rebound congestion (rhinitis medicamentosa) with prolonged use. * **Less Common:** Dizziness, headache, insomnia, palpitations, increased blood pressure. ## Key Drug Interactions * **MAO Inhibitors:** Concomitant use can potentiate the hypertensive effects of oxymetazoline. Avoid use within 14 days of MAO inhibitor discontinuation. * **Other Sympathomimetics:** May increase the risk of cardiovascular side effects. ## Monitoring * Monitor for rebound congestion with prolonged or frequent use (typically > 3 days). * Assess blood pressure and heart rate, especially in patients with pre-existing cardiovascular conditions or those using other sympathomimetics. ## Clinical Pearls * Limit use to a maximum of 3 consecutive days to prevent rebound congestion. * Instruct patients to avoid spraying into the eyes. * If symptoms persist after 3 days of use, discontinue and consult a healthcare provider. *** *This information is intended for healthcare professionals. It is essential to consult the most current prescribing information and relevant literature before making any clinical decisions. Dosing and recommendations may vary based on individual patient factors and local protocols.*