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# Oxymetazoline Nasal Spray ## Overview Oxymetazoline is a topical alpha-adrenergic agonist that causes vasoconstriction of nasal mucosa, reducing swelling and congestion. ## Primary Indications Temporary relief of nasal congestion associated with the common cold, allergic rhinitis, or sinusitis. ## Adult Dosing **Sinex (0.05% solution):** Instill 2 to 3 sprays in each nostril every 10 to 12 hours as needed. Do not exceed 2 doses in a 24-hour period. Limit use to a maximum of 3 days. ## Pediatric Dosing **Children 6 to 11 years:** Instill 2 to 3 sprays in each nostril every 10 to 12 hours as needed. Do not exceed 2 doses in a 24-hour period. Limit use to a maximum of 3 days. **Children under 6 years:** Not recommended. Consult a pediatrician. ## Dose Adjustments No specific dose adjustments are generally required for hepatic or renal impairment. ## Contraindications Hypersensitivity to oxymetazoline or any component of the formulation. Patients with narrow-angle glaucoma. ## Adverse Effects Common: Nasal discomfort, burning, stinging, sneezing, increased nasal discharge. Less Common: Rebound congestion (rhinitis medicamentosa) with prolonged use, dizziness, nervousness, insomnia, palpitations, headache. ## Key Drug Interactions * **MAO inhibitors and tricyclic antidepressants:** May potentiate the hypertensive effects of oxymetazoline. Avoid concurrent use or use with extreme caution. ## Monitoring Monitor for signs of rebound congestion (rhinitis medicamentosa) with prolonged or excessive use. Assess for cardiovascular effects (e.g., increased blood pressure, palpitations) if systemic absorption is suspected. ## Clinical Pearls * Limit use to 3 consecutive days to prevent rebound congestion. * If congestion persists beyond 3 days, discontinue use and consult a healthcare provider. * Shake well before use. * Avoid contact with eyes. --- *This information is intended for clinical decision-making and does not replace the need to consult the most current prescribing information and relevant literature.*