Please check your internet connection and try again.
# Liquid Paraffin
## Overview
Liquid paraffin is a mineral oil used as a laxative. It works by lubricating the stool and intestinal walls, softening the stool and making it easier to pass.
## Primary Indications
* Constipation
## Adult Dosing
* **Oral:** 10 mL to 40 mL once daily.
## Pediatric Dosing
* **Children 1-11 years:** 5 mL to 10 mL once daily.
* **Children >11 years:** Dosing as per adult.
* **Note:** Use in infants and very young children should be under medical supervision due to the risk of aspiration.
## Dose Adjustments
* No specific dose adjustments are typically required for renal or hepatic impairment.
## Contraindications
* Appendicitis or undiagnosed abdominal pain.
* Intestinal obstruction or perforation.
* Dysphagia (risk of aspiration).
* Hypersensitivity to liquid paraffin.
## Adverse Effects
* Anal leakage (common, especially with higher doses).
* Abdominal cramping.
* Nausea.
* Vomiting.
* Lipoid pneumonia (if aspirated).
* Fat-soluble vitamin malabsorption (with chronic use).
## Key Drug Interactions
* **Mineral Oil:** Absorption of fat-soluble vitamins (A, D, E, K) and other lipophilic drugs may be reduced. Administer at least 2 hours apart from these medications.
## Monitoring
* Bowel movements (frequency, consistency).
* Signs of anal leakage or perianal irritation.
* Signs of aspiration or lipoid pneumonia (especially in children or those with swallowing difficulties).
## Clinical Pearls
* Administer at bedtime to minimize anal leakage during the day.
* Advise patients to report any signs of difficulty swallowing or coughing during or after administration.
* Long-term use may lead to dependence and reduced absorption of fat-soluble vitamins.
***
*This information is intended for clinical pharmacists and healthcare professionals. It is essential to consult the most current prescribing information and institutional protocols for definitive guidance.*
