Liquid%2525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252520paraffin

# Liquid Paraffin ## Overview Liquid paraffin is a mineral oil used as an emollient and laxative. It lubricates the intestinal tract, softening stool and easing defecation. ## Primary Indications * Constipation ## Adult Dosing * **Laxative:** 10-30 mL once daily, typically at bedtime. The dose can be adjusted based on response. ## Pediatric Dosing * Dosing for children is generally lower and should be guided by a healthcare provider. A common starting point for children over 12 years is 10 mL once daily. For younger children, consult specific pediatric formularies or a pediatrician. There is limited data for infants. ## Dose Adjustments * No specific dose adjustments are typically required for hepatic or renal impairment. ## Contraindications * Hypersensitivity to liquid paraffin. * Intestinal obstruction. * Appendicitis, or undiagnosed abdominal pain. * Use with caution in patients with dysphagia due to the risk of aspiration and lipoid pneumonia. ## Adverse Effects * Anal leakage or seepage of oil. * Abdominal cramping or discomfort. * Nausea, vomiting. * Risk of lipoid pneumonia if aspirated, particularly in the elderly or those with impaired swallowing. * Reduced absorption of fat-soluble vitamins (A, D, E, K) with chronic use. ## Key Drug Interactions * **Mineral Oil:** Concurrent use with mineral oil can decrease the absorption of fat-soluble vitamins (A, D, E, K) and may reduce the absorption of other lipophilic medications. Separate administration by at least 2 hours. ## Monitoring * Monitor for bowel movements and consistency. * Assess for adverse effects, particularly anal leakage and signs of aspiration. * Consider monitoring for vitamin deficiencies with long-term use. ## Clinical Pearls * Administer at bedtime to minimize disruption and potential anal leakage during the day. * Educate patients about potential anal leakage and suggest using a pad if necessary. * Advise against use in patients with difficulty swallowing. * Chronic use can lead to dependence and malabsorption of fat-soluble vitamins. *** *Disclaimer: This information is intended for healthcare professionals. Always consult the most current prescribing information and local protocols before initiating therapy.*