Liquid%2525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252520paraffin

# Liquid Paraffin ## Overview Liquid paraffin is a mineral oil, a liquid hydrocarbon mixture. It acts as an emollient and lubricant. ## Primary Indications Constipation ## Adult Dosing * **Oral:** 10-45 mL once daily, typically at bedtime. Doses may be adjusted based on patient response. ## Pediatric Dosing * **Oral:** Dosing varies by age. * **1-5 years:** 5 mL once daily. * **6-12 years:** 10 mL once daily. * **Over 12 years:** As per adult dosing. * *Note: Use in infants under 1 year is generally not recommended due to increased risk of aspiration.* ## Dose Adjustments No specific dose adjustments are generally required for hepatic or renal impairment. ## Contraindications * Hypersensitivity to liquid paraffin. * Concurrent use with abdominal pain of unknown origin, nausea, vomiting, or fever. * Individuals with difficulty swallowing due to the risk of aspiration and lipoid pneumonia. ## Adverse Effects * **Common:** Abdominal cramps, diarrhea, anal leakage, and perianal irritation. * **Serious:** Lipoid pneumonia (if aspirated into the lungs), particularly in the elderly, debilitated, or those with impaired swallowing reflexes. ## Key Drug Interactions * **Fat-soluble vitamins (A, D, E, K):** May reduce absorption of these vitamins with chronic use. * **Anticoagulants (e.g., warfarin):** Theoretically, mineral oil can reduce the absorption of vitamin K, potentially increasing anticoagulant effect. Monitor INR closely if used concomitantly. ## Monitoring * Monitor for bowel movements and stool consistency. * Assess for adverse effects, particularly anal leakage and signs of aspiration. * In patients on anticoagulants, monitor INR. ## Clinical Pearls * Administer undiluted, preferably at bedtime. * Avoid administration immediately before lying down. * Not for long-term use; typically recommended for short-term relief of constipation. * The risk of aspiration and lipoid pneumonia is a significant concern, especially in vulnerable populations. *** *This information is intended for healthcare professionals. Always consult the most current prescribing information and local protocols for definitive guidance.*