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# Liquid Paraffin
## Overview
Liquid paraffin is a mineral oil used as a laxative. It works by softening the stool and lubricating the intestinal tract, facilitating easier passage.
## Primary Indications
* Constipation
## Adult Dosing
* **Oral:** 10-20 mL once daily, typically at bedtime. Doses can be increased if needed.
## Pediatric Dosing
* **Oral:** Dosing varies by age and local protocol.
* **Ages 1-5 years:** 5 mL once daily.
* **Ages 6-12 years:** 10 mL once daily.
* **Over 12 years:** As per adult dosing.
* **Note:** Use in infants under 1 year should be under strict medical supervision due to the risk of aspiration.
## Dose Adjustments
No dose adjustments are typically required for hepatic or renal impairment.
## Contraindications
* Hypersensitivity to liquid paraffin.
* Appendicitis, intestinal obstruction, or symptoms of acute abdominal conditions.
* Difficulty swallowing (due to aspiration risk).
* Young children (risk of anal leakage and aspiration).
## Adverse Effects
* Abdominal cramping
* Anal leakage/soiling (especially with higher doses or prolonged use)
* Nausea
* Vomiting
* Lipid pneumonia (rare, with chronic aspiration)
* Reduced absorption of fat-soluble vitamins (A, D, E, K) with chronic use.
## Key Drug Interactions
* May reduce the absorption of fat-soluble vitamins.
* May reduce the absorption of other orally administered medications; separate administration by at least 2 hours.
## Monitoring
* Bowel movements (frequency and consistency)
* Signs of anal leakage or soiling.
* Signs of vitamin deficiencies with chronic use.
## Clinical Pearls
* Administer undiluted and at bedtime to minimize the risk of aspiration.
* Do not lie down immediately after taking.
* Prolonged or excessive use can lead to dependence and interfere with nutrient absorption.
* Effectiveness can take 6-12 hours.
* Avoid use in patients with a history of aspiration or swallowing difficulties.
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*Disclaimer: This information is intended for clinical use and is not a substitute for professional medical advice. Always consult the most current prescribing information and relevant guidelines before making any treatment decisions.*
