Please check your internet connection and try again.
# Liquid Paraffin
## Overview
Liquid paraffin is a mineral oil used as a lubricant laxative. It coats the fecal mass, softening it and easing defecation. It is not absorbed by the body.
## Primary Indications
* Constipation
## Adult Dosing
* **Oral:** 10-45 mL once daily, typically at bedtime. Doses may vary; consult local protocols.
* **Rectal (as enema):** Consult product labeling or local protocols for specific volume and administration.
## Pediatric Dosing
* **Children 6-12 years:** 5-15 mL once daily.
* **Children 1-5 years:** 5 mL once daily.
* **Infants under 1 year:** Not generally recommended; consult a pediatrician. Use with extreme caution and under medical supervision if prescribed.
## Dose Adjustments
No specific dose adjustments are typically required for renal or hepatic impairment due to minimal systemic absorption.
## Contraindications
* Appendicitis or undiagnosed abdominal pain
* Intestinal obstruction
* Fecal impaction
* Dysphagia (risk of aspiration)
* Concurrent use of docusate sodium (increased absorption of liquid paraffin)
* Pregnancy and breastfeeding (generally considered safe, but consult physician)
## Adverse Effects
* **Common:** Abdominal cramping, diarrhea, anal leakage.
* **Less Common/Serious:** Lipoid pneumonia (if aspirated, particularly in the elderly or those with impaired gag reflexes), vitamin malabsorption (with chronic, high-dose use).
## Key Drug Interactions
* **Docusate sodium:** Concurrent use increases the absorption of liquid paraffin, leading to potential adverse effects. Avoid coadministration.
* **Fat-soluble vitamins (A, D, E, K):** Long-term, regular use may reduce the absorption of these vitamins.
## Monitoring
* Bowel movements and stool consistency.
* Signs of abdominal pain, cramping, or rectal leakage.
* Monitor for signs of aspiration if risk factors are present.
## Clinical Pearls
* Administer undiluted. Do not mix with warm liquids, as this increases the risk of aspiration.
* Advise patients to remain in an upright position during and after administration to minimize aspiration risk.
* Long-term, regular use is not recommended due to potential for dependency and vitamin malabsorption.
* Onset of action is typically 6-8 hours.
* Avoid use in patients with dysphagia or impaired gag reflexes.
***
*This information is intended for healthcare professionals. Always consult the official prescribing information and current clinical guidelines for the most up-to-date and comprehensive details.*
