Liquid%252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252520paraffin

## Liquid Paraffin ### Overview Liquid paraffin is a mineral oil used as a laxative and emollient. It works by lubricating the fecal mass and intestinal walls, softening stool and easing defecation. ### Primary Indications * Constipation ### Adult Dosing * **Laxative:** 10-30 mL by mouth once daily, typically at bedtime. Doses may be adjusted based on response, up to a maximum of 45 mL daily. ### Pediatric Dosing * **Laxative:** * **1-5 years:** 5 mL by mouth once daily. * **6-12 years:** 10 mL by mouth once daily. * **Over 12 years:** Dosing as per adult. * Dosing should be adjusted based on clinical response. ### Dose Adjustments No specific dose adjustments are typically required for hepatic or renal impairment. ### Contraindications * Intestinal obstruction * Abdominal pain of unknown origin * Nausea or vomiting * Hypersensitivity to liquid paraffin ### Adverse Effects * Diarrhea * Abdominal cramping * Nausea * Anal leakage (especially with higher doses) * Lipoid pneumonia (if aspirated, particularly in infants and the elderly) * Reduced absorption of fat-soluble vitamins (with chronic use) ### Key Drug Interactions * **Fat-soluble vitamins (A, D, E, K):** Reduced absorption with concurrent use, especially with chronic administration. ### Monitoring * Bowel movements and consistency * Signs of abdominal discomfort or obstruction * For chronic use, monitor for potential vitamin deficiencies. ### Clinical Pearls * Administer at bedtime to minimize daytime leakage. * Avoid use in patients at risk of aspiration, such as those with dysphagia or impaired gag reflex. * Long-term daily use is generally not recommended due to potential for dependency and impaired nutrient absorption. * Ensure adequate fluid intake when using laxatives. *** **Disclaimer:** This information is intended for healthcare professionals and is not a substitute for professional medical advice. Always consult the most current prescribing information and relevant guidelines before making clinical decisions.