Please check your internet connection and try again.
# Liquid Paraffin
## Overview
Liquid paraffin is a mineral oil used as an emollient and a laxative. It lubricates the intestinal tract, softening the stool and easing defecation.
## Primary Indications
* Constipation
## Adult Dosing
* **Laxative:** 10-30 mL once daily, typically at bedtime. Maximum dose is generally considered 30 mL daily.
## Pediatric Dosing
* **Constipation:** Dosing is variable and should be individualized by a healthcare provider.
* **Ages 1-11 years:** Typically 5-10 mL once daily.
* **Ages 12+ years:** Similar to adult dosing (10-30 mL once daily).
* **Note:** Prolonged or frequent use in children is generally discouraged due to potential for lipid pneumonia if aspirated.
## Dose Adjustments
No dose adjustments are typically required for renal or hepatic impairment.
## Contraindications
* Hypersensitivity to liquid paraffin.
* Concurrent use with docusate.
* Abdominal pain of unknown origin, nausea, vomiting, or signs of intestinal obstruction.
* Patients with difficulty swallowing due to the risk of lipid pneumonia from aspiration.
## Adverse Effects
* Diarrhea, abdominal cramping, nausea.
* Anal leakage, particularly with higher doses or in patients with poor sphincter control.
* Risk of lipid pneumonia if aspirated (especially in infants, elderly, or debilitated patients).
* Interference with absorption of fat-soluble vitamins (A, D, E, K) with chronic, high-dose use.
## Key Drug Interactions
* **Docusate:** Concurrent use is contraindicated as it may increase the absorption of mineral oil.
* **Fat-soluble vitamins:** Chronic use may decrease absorption. Separate administration by several hours if necessary.
## Monitoring
* Bowel movement frequency and consistency.
* Signs of anal leakage or abdominal discomfort.
* In children, monitor for signs of aspiration.
## Clinical Pearls
* Administer liquid paraffin on an empty stomach to maximize efficacy and minimize aspiration risk.
* Instruct patients to remain upright for at least 2 hours after administration to reduce aspiration risk.
* Avoid prolonged or continuous use. If constipation persists, further evaluation is warranted.
* The risk of lipid pneumonia is a significant concern, particularly in vulnerable populations.
***
**Disclaimer:** This information is intended for healthcare professionals. Always consult the most current prescribing information and relevant guidelines before making clinical decisions. Dosing may vary based on patient-specific factors and local protocols.
