Please check your internet connection and try again.
# Liquid Paraffin
## Overview
Liquid paraffin is a mineral oil used as a laxative. It lubricates the stool and intestinal walls, easing passage. It is not absorbed systemically.
## Primary Indications
Constipation.
## Adult Dosing
* **Oral:** 15-45 mL once daily, typically at bedtime. Maximum daily dose is typically 45 mL. Dosing may be adjusted based on clinical response and local protocol.
## Pediatric Dosing
* **Oral:** Dosing varies by age and is often determined by local protocol.
* Children 1-5 years: 5-10 mL once daily.
* Children 6-12 years: 10-15 mL once daily.
* Children >12 years: As per adult dosing.
* **Caution:** Use in infants and very young children should be under medical supervision due to increased risk of aspiration.
## Dose Adjustments
No dose adjustments are typically needed for renal or hepatic impairment as it is not absorbed.
## Contraindications
* Hypersensitivity to liquid paraffin.
* Intestinal obstruction or appendicitis.
* Unexplained abdominal pain.
* Nausea or vomiting.
* Patients with difficulty swallowing (due to aspiration risk).
## Adverse Effects
* Anal leakage or staining.
* Abdominal cramping or discomfort.
* Nausea.
* Lipoid pneumonia (rare, associated with chronic aspiration).
* Decreased absorption of fat-soluble vitamins (A, D, E, K) with chronic, high-dose use.
## Key Drug Interactions
* **Mineral Oil:** Can decrease the absorption of fat-soluble vitamins and oral medications (e.g., digoxin, oral anticoagulants). Administer liquid paraffin at least 2 hours apart from other oral medications or supplements.
## Monitoring
* Bowel movements (frequency, consistency).
* Signs of abdominal obstruction.
* Signs of aspiration.
## Clinical Pearls
* Administer at bedtime to minimize daytime inconvenience from potential anal leakage.
* Advise patients to avoid lying down immediately after taking liquid paraffin to reduce aspiration risk.
* Long-term use may interfere with nutrient absorption; consider vitamin supplementation if used chronically, especially in children or the elderly.
* Not intended for chronic use; lifestyle modifications (diet, fluid intake, exercise) are preferred for long-term management of constipation.
---
***Disclaimer:** This information is intended for clinical use and is not a substitute for professional medical advice. Always consult the most current prescribing information and local protocols before administering any medication.*
