Please check your internet connection and try again.
# Isoxsuprine hydrochloride
## Overview
Isoxsuprine hydrochloride is a peripheral vasodilator.
## Primary Indications
* Adjunctive treatment of peripheral arterial insufficiency (e.g., intermittent claudication).
* Management of cerebrovascular insufficiency.
* Certain conditions associated with vasospasm.
## Adult Dosing
* **Peripheral Arterial Insufficiency:** 10-20 mg orally 3-4 times daily.
* **Cerebrovascular Insufficiency:** 10-20 mg orally 3-4 times daily.
* Maximum dose: 40 mg per dose, 160 mg daily.
## Pediatric Dosing
No established pediatric dosing.
## Dose Adjustments
No specific dose adjustments are typically required for renal or hepatic impairment, but caution is advised.
## Contraindications
* Hypersensitivity to isoxsuprine.
* Use in patients with congenital heart disease or hypotension is generally not recommended due to potential for vasodilation.
## Adverse Effects
* **Common:** Hypotension, tachycardia, flushing, nausea, vomiting, abdominal distress, dizziness, weakness, nervousness.
* **Less Common:** Rash, epigastric distress.
## Key Drug Interactions
* **Antihypertensives:** May potentiate hypotensive effects.
* **Other Vasodilators:** Additive effects leading to significant hypotension.
## Monitoring
* Blood pressure and heart rate.
* Symptoms of peripheral vascular disease (e.g., claudication distance, rest pain).
* Signs of adverse effects.
## Clinical Pearls
* Efficacy in many of its indicated uses is not well-established by rigorous clinical trials.
* May cause drowsiness; patients should exercise caution when driving or operating machinery.
* Dosing frequency and individual patient response should guide therapy.
---
*This information is intended for healthcare professionals. Always consult the current prescribing information and relevant clinical guidelines before making treatment decisions.*
