Please check your internet connection and try again.
# Isoxsuprine hydrochloride
## Overview
Isoxsuprine hydrochloride is a peripheral vasodilator.
## Primary Indications
* Treatment of peripheral vascular disease (PVD) and intermittent claudication.
* To improve collateral circulation in conditions such as cerebrovascular insufficiency.
## Adult Dosing
* **Initial Dose:** 10 mg orally every 4 to 6 hours.
* **Maintenance Dose:** May be increased gradually up to 20 mg orally every 4 to 6 hours.
* **Maximum Daily Dose:** Not to exceed 120 mg orally per day.
## Pediatric Dosing
* No established pediatric dosing recommendations. Use is generally not recommended in pediatric patients.
## Dose Adjustments
* No specific dose adjustments are routinely recommended for renal or hepatic impairment, but caution is advised.
## Contraindications
* Hypersensitivity to isoxsuprine.
* Do not administer intravenously; it is intended for oral use only.
## Adverse Effects
* **Common:** Nausea, vomiting, gastrointestinal distress, dizziness, weakness, flushing, headache.
* **Less Common:** Hypotension, rash, abdominal pain, nervousness, drowsiness.
## Key Drug Interactions
* **Antihypertensives:** May potentiate hypotensive effects.
* **Other Vasodilators:** Additive hypotensive effects may occur.
## Monitoring
* Monitor blood pressure and heart rate.
* Assess for improvement in symptoms of peripheral vascular disease.
* Observe for adverse effects.
## Clinical Pearls
* Efficacy in PVD and cerebrovascular insufficiency is controversial and not well-established by robust clinical trials.
* Onset of action may take several weeks.
* Administer with food if gastrointestinal upset occurs.
***
**Disclaimer:** This information is intended for healthcare professionals and should not replace professional medical advice. Always consult the most current prescribing information and clinical guidelines for complete details and to verify dosages and recommendations.
