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# Isoxsuprine Hydrochloride
## Overview
Isoxsuprine hydrochloride is a peripheral vasodilator and smooth muscle relaxant.
## Primary Indications
* Treatment of peripheral vascular diseases such as arteriosclerosis obliterans, Buerger's disease, and Raynaud's disease.
* Adjunctive therapy for cerebrovascular insufficiency.
* Historically used for premature labor, but this use is no longer recommended due to safety concerns.
## Adult Dosing
* **Oral:** 10 mg to 20 mg three to four times daily.
* **Maximum:** Doses up to 40 mg four times daily have been used, but higher doses are associated with increased adverse effects.
## Pediatric Dosing
No established pediatric dosing. Safety and efficacy have not been determined.
## Dose Adjustments
No specific dose adjustments are established for renal or hepatic impairment. Use with caution.
## Contraindications
* Hypersensitivity to isoxsuprine.
* Use in the immediate postpartum period.
* Use in patients with cardiac arrhythmias or conduction defects.
## Adverse Effects
* **Common:** Hypotension, flushing, dizziness, nausea, vomiting, gastric distress, rash.
* **Less Common:** Tachycardia, palpitations, weakness, nervousness, drowsiness.
* **Rare:** Gastrointestinal bleeding.
## Key Drug Interactions
* **Antihypertensives:** Isoxsuprine can potentiate the hypotensive effects of antihypertensive medications.
* **Other Vasodilators:** Additive hypotensive effects may occur.
## Monitoring
* Blood pressure (monitor for hypotension).
* Heart rate (monitor for tachycardia).
* Symptoms of peripheral vascular disease.
## Clinical Pearls
* Onset of action may take several weeks.
* Advise patients to avoid sudden changes in posture due to potential orthostatic hypotension.
* Discontinue if paradoxical decrease in circulation or worsening of symptoms occurs.
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*This information is intended for healthcare professionals. Please verify current prescribing information and local protocols before administration.*
