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# Isoxsuprine hydrochloride
## Overview
Isoxsuprine hydrochloride is a vasodilator with beta-adrenergic agonist properties.
## Primary Indications
* Treatment of peripheral vascular disease (e.g., intermittent claudication) to improve blood supply to the extremities.
* Historically used for threatened premature labor, but this indication is generally no longer recommended due to safety concerns and lack of efficacy compared to other agents.
## Adult Dosing
* **Peripheral Vascular Disease:** 10-20 mg orally 3 to 4 times daily.
* **Maximum Dose:** Not clearly defined, but exceeding 80 mg per day is generally not recommended.
## Pediatric Dosing
* No established pediatric dosing. Use is generally not recommended.
## Dose Adjustments
* No specific dose adjustments are typically required for renal or hepatic impairment, but caution is advised.
## Contraindications
* Hypersensitivity to isoxsuprine hydrochloride.
* Avoid use in patients with recent myocardial infarction, arrhythmias, or glaucoma.
## Adverse Effects
* **Common:** Nausea, vomiting, gastrointestinal distress, dizziness, weakness, flushing, nervousness, and rash.
* **Less Common:** Hypotension, tachycardia, and paradoxical bronchospasm.
## Key Drug Interactions
* **Antihypertensives:** May potentiate hypotensive effects.
* **Other Vasodilators:** Increased risk of hypotension.
## Monitoring
* Blood pressure and heart rate.
* Signs and symptoms of peripheral vascular disease.
* Signs of adverse effects.
## Clinical Pearls
* Efficacy in peripheral vascular disease is variable and should be weighed against potential adverse effects.
* Oral administration may be associated with significant gastrointestinal upset; taking with food may help.
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**Disclaimer:** This information is intended for healthcare professionals and does not replace clinical judgment or current prescribing information. Always verify drug information with the most up-to-date product labeling and relevant guidelines.
