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# Isoxsuprine hydrochloride
## Overview
Isoxsuprine hydrochloride is a peripheral vasodilator.
## Primary Indications
* Adjunctive therapy in intermittent claudication and other peripheral vascular diseases.
## Adult Dosing
* **Intermittent Claudication and Peripheral Vascular Disease:** 10-20 mg by mouth every 6 to 8 hours.
* **Maximum Dose:** 80 mg per day.
## Pediatric Dosing
* No established pediatric dosing. Use in children is not recommended.
## Dose Adjustments
* No specific dose adjustments are routinely recommended for hepatic or renal impairment, but caution may be warranted.
## Contraindications
* Do not administer to patients who have had a recent (within 3 months) myocardial infarction.
* Do not administer to patients with severe bradycardia or advanced AV block.
* Hypersensitivity to isoxsuprine.
## Adverse Effects
* **Common:** Nausea, vomiting, stomach upset, dizziness, lightheadedness, weakness, flushing, rash.
* **Serious:** Hypotension, cardiac arrhythmias, tachycardia, chest pain.
## Key Drug Interactions
* **Antihypertensives:** May potentiate hypotensive effects.
* **Alpha-adrenergic blockers:** May antagonize alpha-blocking effects.
## Monitoring
* Blood pressure.
* Heart rate.
* Symptoms of peripheral vascular disease (e.g., claudication).
## Clinical Pearls
* Efficacy in peripheral vascular disease is controversial and not universally accepted.
* Consider alternatives with stronger evidence.
* Administer with food or milk to minimize gastrointestinal upset.
**Disclaimer:** This information is intended for healthcare professionals. Always consult the most current prescribing information and institutional protocols before making clinical decisions.
