Isoxsuprine%25252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252520hydrochloride

# Isoxsuprine Hydrochloride ## Overview Isoxsuprine hydrochloride is a peripheral vasodilator. ## Primary Indications * Peripheral arterial insufficiency (e.g., intermittent claudication) * Cerebrovascular insufficiency ## Adult Dosing * **Peripheral Arterial Insufficiency:** 10 mg to 20 mg orally three to four times daily. * **Cerebrovascular Insufficiency:** 10 mg to 20 mg orally three to four times daily. ## Pediatric Dosing * No established pediatric dosing. ## Dose Adjustments * No specific dose adjustments recommended for renal or hepatic impairment. However, caution and reduced dosage may be warranted in patients with severe impairment due to potential accumulation. ## Contraindications * Use with caution in patients with hypotension. ## Adverse Effects * Hypotension * Dizziness * Nausea * Vomiting * Abdominal distress * Weakness * Flushing * Palpitations * Rash ## Key Drug Interactions * **Antihypertensives:** May potentiate hypotensive effects. ## Monitoring * Blood pressure * Symptoms of peripheral or cerebrovascular insufficiency ## Clinical Pearls * Efficacy in peripheral arterial insufficiency is controversial. * Oral administration is preferred. *** *Disclaimer: This information is intended for healthcare professionals. Please consult the most current prescribing information and relevant clinical guidelines for definitive guidance.*