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# Isoxsuprine hydrochloride
## Overview
Isoxsuprine hydrochloride is a vasodilator.
## Primary Indications
Treatment of peripheral vascular diseases such as intermittent claudication and vasospasm.
## Adult Dosing
* **Intermittent Claudication/Peripheral Vascular Disease:** 10 mg to 20 mg orally three to four times daily.
* Maximum dose: 80 mg per day.
## Pediatric Dosing
* Information regarding pediatric dosing is not established.
## Dose Adjustments
* No specific dose adjustments are recommended for renal or hepatic impairment, but caution is advised.
## Contraindications
* Hypersensitivity to isoxsuprine hydrochloride.
* Do not administer in the early postpartum period or in patients with glaucoma or tachycardia.
## Adverse Effects
* **Common:** Nausea, vomiting, stomach upset, dizziness, weakness, flushing, rash.
* **Serious:** Hypotension, tachycardia, drowsiness, blurred vision.
## Key Drug Interactions
* **Antihypertensives:** May potentiate hypotensive effects.
* **Sympathomimetics:** May increase cardiovascular effects (tachycardia, arrhythmias).
## Monitoring
* Blood pressure.
* Heart rate.
* Symptoms of peripheral vascular disease.
## Clinical Pearls
* Efficacy in peripheral vascular disease is controversial and not well-established.
* Administer with food to minimize gastrointestinal upset.
* Advise patients to report any new or worsening symptoms of dizziness, weakness, or cardiovascular changes.
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*Disclaimer: This information is intended for healthcare professionals. Always consult the most current prescribing information and relevant clinical guidelines for complete details and to verify dosages and safety information before prescribing.*
