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# Isoxsuprine hydrochloride
## Overview
Isoxsuprine hydrochloride is a vasodilator that acts primarily on blood vessels.
## Primary Indications
Historically used for peripheral vascular disease, cerebrovascular insufficiency, and premature labor. Its efficacy for these indications is not well-established and it is not FDA-approved for these uses.
## Adult Dosing
* **Peripheral Vascular Disease/Cerebrovascular Insufficiency:** Typically 10-20 mg orally 3-4 times daily. Maximum dose not clearly established, but higher doses may increase adverse effects.
* **Premature Labor:** Dosing varies widely and is often institution-specific. A common regimen involves an initial IV dose followed by oral maintenance doses, but this use is controversial and not FDA-approved.
## Pediatric Dosing
There is no established pediatric dosing for isoxsuprine hydrochloride.
## Dose Adjustments
No specific dose adjustments are recommended for renal or hepatic impairment, but caution is advised due to potential for increased adverse effects.
## Contraindications
* Known hypersensitivity to isoxsuprine hydrochloride.
* Administering to patients in whom a rapid heart rate is undesirable (e.g., certain cardiac conditions).
## Adverse Effects
Common adverse effects include flushing, nausea, vomiting, dizziness, weakness, hypotension, and tachycardia.
## Key Drug Interactions
* **Antihypertensives:** May potentiate hypotensive effects.
* **Vasodilators:** Additive hypotensive effects.
## Monitoring
* Blood pressure and heart rate.
* Signs and symptoms of adverse effects.
## Clinical Pearls
* The clinical utility of isoxsuprine hydrochloride for its historical indications is questionable due to limited robust evidence.
* Use with caution in patients with cardiovascular disease.
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**Disclaimer:** This information is intended for clinical pharmacy professionals. Always consult the most current prescribing information and relevant clinical guidelines for definitive guidance.
