Isoxsuprine%25252525252525252525252525252525252525252525252525252525252525252525252525252525252525252525252520hydrochloride

# Isoxsuprine hydrochloride ## Overview Isoxsuprine hydrochloride is a non-ergot vasodilator used to improve blood flow. ## Primary Indications * Peripheral vascular diseases, such as intermittent claudication and vasospastic conditions. * Cerebrovascular insufficiency. ## Adult Dosing * **Oral:** 10 mg to 20 mg three to four times daily. * **Maximum:** 80 mg daily. ## Pediatric Dosing * There is no established pediatric dosing. Use is generally not recommended. ## Dose Adjustments * No specific dose adjustments are routinely recommended for hepatic or renal impairment, but caution is advised. ## Contraindications * Hypersensitivity to isoxsuprine hydrochloride. * Not recommended for use immediately postpartum or in patients with congenital heart defects. ## Adverse Effects * **Common:** Tachycardia, hypotension, flushing, dizziness, nausea, vomiting, abdominal distress, rash. * **Less Common:** Weakness, nervousness, drowsiness. ## Key Drug Interactions * **Antihypertensives:** May potentiate hypotensive effects. * **Epinephrine:** May antagonize the vasodilating effects of isoxsuprine. ## Monitoring * Blood pressure and heart rate. * Signs and symptoms of peripheral vascular disease. ## Clinical Pearls * Efficacy in cerebrovascular insufficiency is controversial. * Patient should be advised to avoid prolonged exposure to heat, as it can exacerbate vasodilation and hypotension. * Discontinue if adverse effects occur. **Disclaimer:** This information is intended for healthcare professionals. Always consult the most current prescribing information and relevant literature before making clinical decisions.