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# Isoxsuprine hydrochloride
## Overview
Isoxsuprine hydrochloride is a vasodilator. Its exact mechanism of action is not fully understood, but it is believed to cause relaxation of vascular smooth muscle, leading to vasodilation.
## Primary Indications
* Intermittent claudication due to peripheral vascular disease.
* Cerebrovascular insufficiency.
## Adult Dosing
* **Intermittent Claudication/Cerebrovascular Insufficiency:** 10 mg to 20 mg orally three to four times daily.
* **Maximum Daily Dose:** Not explicitly defined, but typically does not exceed 80 mg per day.
## Pediatric Dosing
No established pediatric dosing recommendations.
## Dose Adjustments
No specific dose adjustments are routinely recommended for hepatic or renal impairment. However, caution is advised in patients with severe hepatic or renal disease.
## Contraindications
* Hypersensitivity to isoxsuprine hydrochloride.
* Should not be administered intravenously (IV).
## Adverse Effects
* **Common:** Hypotension, dizziness, flushing, nausea, vomiting, abdominal distress, headache.
* **Less Common:** Tachycardia, nervousness, weakness, rash.
## Key Drug Interactions
* **Antihypertensives:** Isoxsuprine can potentiate the effects of antihypertensive medications, leading to additive hypotension. Monitor blood pressure closely.
## Monitoring
* Blood pressure, especially when used concomitantly with antihypertensive agents.
* Signs and symptoms of peripheral vascular disease.
## Clinical Pearls
* Isoxsuprine is primarily used for symptomatic relief and does not cure the underlying vascular disease.
* Effectiveness in certain indications, such as cerebrovascular insufficiency, is controversial and not well-established by robust clinical trials.
* Intravenous administration is contraindicated.
**Disclaimer:** This information is intended for healthcare professionals. Always consult the most current prescribing information and relevant literature for complete details and to ensure patient safety.
