Isoxsuprine%2525252525252525252525252525252525252525252520hydrochloride

# Isoxsuprine hydrochloride ## Overview Isoxsuprine hydrochloride is a vasodilator with some $\beta$-adrenergic agonist activity. It is thought to relax vascular smooth muscle, leading to vasodilation and improved blood flow. ## Primary Indications * Treatment of peripheral vascular disease (e.g., arteriosclerosis obliterans, intermittent claudication, Buerger's disease) to improve blood flow. * Management of cerebrovascular insufficiency. * Adjunctive therapy in Ménière's disease. ## Adult Dosing * **Typical dose:** 10-20 mg orally 3-4 times daily. * **Maximum dose:** Not well established for chronic use. Generally, higher doses are not associated with significantly increased efficacy but may increase the risk of adverse effects. ## Pediatric Dosing * There is no established pediatric dosing for isoxsuprine hydrochloride. Its use in children is generally not recommended due to lack of data and potential risks. ## Dose Adjustments * **Renal impairment:** No specific dose adjustments are established. Use with caution in patients with severe renal impairment. * **Hepatic impairment:** No specific dose adjustments are established. Use with caution in patients with severe hepatic impairment. ## Contraindications * Hypersensitivity to isoxsuprine hydrochloride. * Do not administer to patients recently diagnosed with glaucoma. * Do not administer to patients who have experienced a recent myocardial infarction. *