Please check your internet connection and try again.
Isoxsuprine hydrochloride is a vasodilator.
## Primary Indications
* Adjunctive therapy in conditions associated with impaired peripheral circulation, such as peripheral vascular disease, arteriosclerosis obliterans, and intermittent claudication.
## Adult Dosing
* **Oral:** 10 mg to 20 mg, 3 to 4 times daily.
* **Maximum Daily Dose:** Not well-established, but typically 80 mg per day.
## Pediatric Dosing
* Safety and efficacy in pediatric patients have not been established.
## Dose Adjustments
* No specific dose adjustments are typically required for renal or hepatic impairment, but caution is advised due to limited data.
## Contraindications
* Known hypersensitivity to isoxsuprine hydrochloride.
* Should not be administered immediately postpartum or in the presence of significant hypotension.
## Adverse Effects
* **Common:** Nausea, vomiting, gastrointestinal distress, dizziness, weakness, flushing, headache, rash.
* **Less Common:** Hypotension, tachycardia, chest pain, abdominal pain, nervousness.
## Key Drug Interactions
* **Antihypertensives:** Isoxsuprine may cause hypotension, potentially potentiating the effects of antihypertensive medications.
* **Other Vasodilators:** Additive hypotensive effects may occur.
## Monitoring
* Blood pressure and heart rate.
* Signs and symptoms of peripheral vascular disease.
## Clinical Pearls
* Effectiveness in improving peripheral circulation is debated, and evidence is limited.
* Administer with food if gastrointestinal upset occurs.
***
*Disclaimer: This information is intended for healthcare professionals and is not a substitute for professional medical advice. Always consult the most current prescribing information and your healthcare provider for any medical condition or treatment. Dosing may vary based on individual patient factors and local protocols.*
