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# Ecospirin 75mg Enteric-Coated
## Overview
Ecospirin 75mg Enteric-Coated is a brand name for aspirin, a nonsteroidal anti-inflammatory drug (NSAID) with antiplatelet, analgesic, and antipyretic properties. The enteric coating is designed to delay the release of aspirin until it reaches the small intestine, potentially reducing gastric irritation.
## Primary Indications
* **Cardiovascular prophylaxis:** Prevention of myocardial infarction and stroke in patients with established cardiovascular disease or risk factors.
## Adult Dosing
* **Cardiovascular prophylaxis:** 75 mg orally once daily.
## Pediatric Dosing
* Aspirin is generally not recommended for use in children and adolescents due to the risk of Reye's syndrome, particularly during viral illnesses.
## Dose Adjustments
* No dose adjustments are typically required for renal or hepatic impairment, but caution should be exercised, especially in severe disease.
## Contraindications
* Hypersensitivity to aspirin, salicylates, or NSAIDs.
* Active peptic ulceration or gastrointestinal bleeding.
* History of bronchospasm, urticaria, or allergic-type reactions after aspirin or NSAID administration.
* Severe hepatic impairment.
* Severe renal impairment.
* Children and adolescents with viral infections (risk of Reye's syndrome).
* Use in the third trimester of pregnancy.
## Adverse Effects
* **Gastrointestinal:** Dyspepsia, nausea, vomiting, abdominal pain, heartburn, occult bleeding. More serious GI bleeding and ulceration can occur.
* **Hematologic:** Increased bleeding time, bruising, epistaxis.
* **Hypersensitivity:** Bronchospasm, urticaria, angioedema, anaphylaxis.
* **Other:** Tinnitus (especially at higher doses), dizziness, headache.
## Key Drug Interactions
* **Anticoagulants (e.g., warfarin, heparin, DOACs):** Increased risk of bleeding.
* **Other NSAIDs and salicylates:** Increased risk of GI toxicity and bleeding.
* **Corticosteroids:** Increased risk of GI ulceration and bleeding.
* **Methotrexate:** Increased methotrexate levels and toxicity.
* **Selective Serotonin Reuptake Inhibitors (SSRIs):** Increased risk of bleeding.
* **Alcohol:** Increased risk of GI irritation and bleeding.
* **Antihypertensives (e.g., ACE inhibitors, ARBs, beta-blockers):** Aspirin may reduce their efficacy.
* **Uricosuric agents (e.g., probenecid):** Aspirin may reduce their uricosuric effect.
## Monitoring
* Signs and symptoms of gastrointestinal bleeding (e.g., melena, hematemesis, abdominal pain).
* Signs and symptoms of bleeding elsewhere (e.g., bruising, epistaxis, prolonged bleeding from cuts).
* Renal function if other nephrotoxic agents are used or in patients with pre-existing renal disease.
* Liver function if signs of hepatic dysfunction develop.
## Clinical Pearls
* The enteric coating aims to reduce gastric upset, but GI side effects can still occur. Taking with food may further help.
* Even at low doses, aspirin carries a risk of bleeding. Patients should be advised to report any signs of bleeding.
* Patients should be instructed to discontinue aspirin at least 5-7 days prior to elective surgery or dental procedures, after consulting their physician.
* Consider alternative analgesics if gastric symptoms are problematic or if there is a history of peptic ulcer disease.
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**Disclaimer:** This information is for educational purposes only and does not substitute for professional medical advice. Always verify the most current prescribing information with the manufacturer or a reliable drug reference before making any treatment decisions.
