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# Citral ## Overview Citral is a mixture of two acyclic monoterpene acyclic alcohols, geranial and neral. It is found naturally in the oils of several plants, including lemon myrtle, lemon verbena, and citrus fruits. ## Primary Indications Citral is primarily used as a flavoring agent in food and beverages and as a fragrance ingredient in cosmetics and personal care products. There is limited evidence supporting its use as a therapeutic agent. Some research suggests potential antimicrobial, anti-inflammatory, and anxiolytic properties, but these are not established indications. ## Adult Dosing As a flavoring and fragrance agent, there are no specific dosing guidelines. Usage is typically determined by product formulation and regulatory limits. ## Pediatric Dosing There are no established pediatric dosing guidelines for citral. ## Dose Adjustments Dose adjustments are not applicable as citral is not dosed therapeutically. ## Contraindications * Hypersensitivity to citral. * Use with caution in individuals with sensitive skin, as it may cause allergic contact dermatitis. ## Adverse Effects * Skin irritation and allergic contact dermatitis. * Photosensitivity reactions have been reported. * When ingested in large quantities, gastrointestinal upset may occur. ## Key Drug Interactions No significant drug interactions are established for citral when used at levels typical for flavoring and fragrance. ## Monitoring Monitoring is not typically required when citral is used at approved levels for flavoring and fragrance. If used investigationaly, monitor for skin reactions and signs of gastrointestinal upset. ## Clinical Pearls * Citral is generally recognized as safe (GRAS) for use as a food flavoring agent by the FDA when used in accordance with good manufacturing practices. * Due to its potential to cause skin sensitization, its use in cosmetics is regulated, with restrictions on concentration in leave-on products. *** **Disclaimer:** This information is intended for healthcare professionals. Always consult the most current prescribing information, product monographs, or relevant regulatory guidelines before making any clinical decisions.