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# Citral ## Overview Citral is a mixture of two acyclic monoterpene geometric isomers, geranial and neral. It is found naturally in the oils of several plants, including lemon myrtle, lemon verbena, lemongrass, and lemon balm. It is used in flavoring and fragrance applications. Its therapeutic uses are not well-established in mainstream medicine. ## Primary Indications Citral does not have widely recognized primary indications in conventional pharmacotherapy. Its use is primarily in the food, beverage, and fragrance industries. Some *in vitro* and animal studies suggest potential antimicrobial, anti-inflammatory, and anxiolytic properties, but these have not translated into established clinical uses. ## Adult Dosing There is no established adult dosing for citral as a therapeutic agent. ## Pediatric Dosing There is no established pediatric dosing for citral as a therapeutic agent. ## Dose Adjustments Dose adjustments are not applicable as there are no established therapeutic doses. ## Contraindications * Hypersensitivity to citral. * Generally recognized as safe (GRAS) status for food use, but specific contraindications for therapeutic applications are not defined due to lack of established use. ## Adverse Effects When used in food or fragrance, citral can cause: * Contact dermatitis (especially in individuals with pre-existing skin conditions or atopic dermatitis). * Photosensitivity reactions. * Oral irritation or allergic reactions in sensitive individuals. ## Key Drug Interactions No significant drug interactions are established due to its limited therapeutic use. ## Monitoring Monitoring is not applicable due to the lack of established therapeutic use and dosing. ## Clinical Pearls * Citral is primarily used as a flavoring agent and fragrance component. * While some preliminary research suggests potential health benefits, these are not supported by robust clinical evidence. * Skin sensitization is a known issue, particularly with topical exposure. *** *Please verify the current prescribing information and consult with a healthcare professional for specific medical advice.*