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# Citral
## Overview
Citral is a naturally occurring acyclic monoterpene aldehyde, a mixture of two geometric isomers, geranial (trans-isomer) and neral (cis-isomer). It is commonly found in the oils of citrus plants like lemon and lemongrass.
## Primary Indications
Citral is primarily used in the fragrance and flavor industry. Therapeutically, it has been investigated for potential antimicrobial, anti-inflammatory, and anticarcinogenic properties, but these are not established indications for general clinical use. It is sometimes used in traditional medicine.
## Adult Dosing
There is no standard FDA-approved dosing for citral in the United States for any indication. Its use in dietary supplements or topical products varies widely.
## Pediatric Dosing
There is no established pediatric dosing for citral.
## Dose Adjustments
Not applicable due to lack of standardized dosing.
## Contraindications
* Known hypersensitivity to citral or components of its formulation.
* Parenteral administration is not recommended due to lack of safety data and potential for severe adverse reactions.
## Adverse Effects
When used topically, citral can cause skin irritation, allergic contact dermatitis, and photosensitivity. Ingestion of large amounts may cause gastrointestinal upset (nausea, vomiting, diarrhea).
## Key Drug Interactions
No significant drug interactions are established for citral due to its limited clinical use. However, concurrent use of other photosensitizing agents may increase the risk of phototoxicity.
## Monitoring
For topical use, monitor for signs of skin irritation or allergic reaction.
## Clinical Pearls
Citral is generally recognized as safe (GRAS) for use as a flavoring agent by the FDA in limited quantities. Its therapeutic applications are investigational.
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