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# Citral ## Overview Citral is a mixture of two acyclic monoterpene geometric isomers, geranial (trans-citral) and neral (cis-citral). It is a component of various essential oils and is used in fragrances and flavorings. Pharmaceutical uses are limited and not well-established. ## Primary Indications There are no FDA-approved indications for citral. It is primarily used as a flavoring agent and fragrance ingredient. Limited research suggests potential anti-inflammatory, antioxidant, and antimicrobial properties, but these are not clinically established indications. ## Adult Dosing Dosing is not established for pharmaceutical use. As a flavoring agent, concentrations are typically very low and dependent on the product formulation. ## Pediatric Dosing Dosing is not established for pediatric pharmaceutical use. ## Dose Adjustments No dose adjustments are established due to lack of defined pharmaceutical dosing. ## Contraindications Hypersensitivity to citral or components of the formulation. ## Adverse Effects Contact dermatitis and skin irritation are the most commonly reported adverse effects, particularly with topical exposure. Due to its volatility, inhalation of high concentrations may cause respiratory irritation. Gastrointestinal upset is possible with oral ingestion of high amounts. ## Key Drug Interactions None well-established for pharmaceutical use. Potential exists for interactions with drugs metabolized by the cytochrome P450 system, but this is theoretical and not clinically documented. ## Monitoring No specific monitoring parameters are established for pharmaceutical use. ## Clinical Pearls Citral is generally recognized as safe (GRAS) by the FDA for use as a flavoring agent at low concentrations. Its use in therapeutic contexts is investigational. Patients with known allergies to essential oils should use caution. *** **Disclaimer:** This information is intended for clinical use and is not a substitute for professional medical advice. Always consult the most current prescribing information and relevant literature before making any treatment decisions. Dosing and recommendations may vary based on patient-specific factors and local protocols.