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# Citral ## Overview Citral is a mixture of two acyclic monoterpene geometric isomers, geranial (trans-citral) and neral (cis-citral). It is found naturally in the oils of many plants, including lemon myrtle, lemon verbena, lemongrass, and lemon. It is primarily used as a flavoring agent and fragrance ingredient. Its therapeutic use is limited and investigational. ## Primary Indications Citral is not approved by the FDA for any medical indication. Its use in medicine is primarily investigational, with some research exploring its potential in areas such as: * Antimicrobial activity * Anti-inflammatory effects * Anticancer properties (preclinical studies) ## Adult Dosing There is no established or FDA-approved adult dosing for citral for any medical condition. Doses used in research settings vary widely and are not suitable for clinical recommendation. ## Pediatric Dosing There is no established or FDA-approved pediatric dosing for citral for any medical condition. ## Dose Adjustments Dose adjustments are not applicable as there are no established therapeutic doses. ## Contraindications * Known hypersensitivity to citral or any component of the product. * Due to lack of established safety, caution is advised in pregnant or breastfeeding individuals. ## Adverse Effects When used in food or as a fragrance, citral can cause skin sensitization and allergic reactions in susceptible individuals. Other potential adverse effects, based on limited investigational use, are poorly characterized but could include gastrointestinal upset. ## Key Drug Interactions No significant drug interactions have been established due to the lack of therapeutic use. However, as a natural product, it may have theoretical interactions with certain metabolic pathways, which are not well-studied. ## Monitoring Monitoring is not established for therapeutic use. In cases of suspected allergic reaction, monitor for signs of hypersensitivity. ## Clinical Pearls * Citral is primarily known for its strong lemon scent and flavor. * Its therapeutic applications are investigational, and it should not be used for self-treatment of any medical condition. * Individuals with known allergies to citrus or fragrance components should exercise caution. *** **Disclaimer:** This information is intended for healthcare professionals and is not a substitute for professional medical advice. Always consult the most current prescribing information and relevant literature before making clinical decisions. Dosing and safety information for investigational agents can be highly variable and may not be well-established.