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# Ceftriaxone
## Overview
Ceftriaxone is a third-generation cephalosporin antibiotic with broad-spectrum activity against many Gram-positive and Gram-negative bacteria. It is administered intravenously or intramuscularly.
## Primary Indications
* Bacterial meningitis
* Community-acquired pneumonia
* Hospital-acquired pneumonia
* Complicated intra-abdominal infections
* Uncomplicated gonorrhea
* Pelvic inflammatory disease
* Febrile neutropenia
* Sepsis
* Prophylaxis for surgical site infections
## Adult Dosing
* **General Infections:** 1 to 2 grams intravenously (IV) or intramuscularly (IM) every 12 to 24 hours.
* **Meningitis:** 2 grams IV every 12 hours.
* **Uncomplicated Gonorrhea:** 250 mg IM once.
* **Febrile Neutropenia:** 2 grams IV every 24 hours.
* **Maximum Dose:** 4 grams per day.
Dosing for specific indications may vary based on local protocols and severity of infection.
## Pediatric Dosing
* **General Infections:** 50 to 100 mg/kg/day IV or IM in divided doses every 12 to 24 hours.
* **Meningitis:** 100 mg/kg/day IV in divided doses every 12 hours. Doses up to 125 mg/kg/day have been used.
* **Neonates (≤ 7 days):** 25 to 50 mg/kg/day IV or IM every 24 hours.
* **Neonates (8 to 28 days):** 50 mg/kg/day IV or IM every 12 hours.
* **Maximum Dose:** 4 grams per day.
Dosing in neonates requires careful consideration due to immature liver and kidney function.
## Dose Adjustments
* **Renal Impairment:** No dose adjustment is generally needed when administered alone, as ceftriaxone is primarily eliminated by hepatic metabolism and biliary excretion. However, in severe renal impairment, caution and monitoring may be advised.
* **Hepatic Impairment:** No dose adjustment is generally needed when administered alone. In combined severe renal and hepatic impairment, monitoring may be necessary.
## Contraindications
* Known hypersensitivity to ceftriaxone, other cephalosporins, or penicillins.
* Neon
