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# Ceftriaxone ## Overview Ceftriaxone is a third-generation cephalosporin antibiotic with broad-spectrum activity against many Gram-positive and Gram-negative bacteria. It is administered intravenously or intramuscularly. ## Primary Indications * Serious bacterial infections including: * Pneumonia * Meningitis (except Listeria) * Sepsis * Gonorrhea * Uncomplicated skin and skin structure infections * Pelvic inflammatory disease * Bone and joint infections * Intra-abdominal infections * Urinary tract infections * Perioperative prophylaxis ## Adult Dosing * **General Infections:** 1 to 2 grams intravenously (IV) or intramuscularly (IM) every 24 hours. * **Severe Infections:** Doses up to 4 grams IV daily have been used. Doses greater than 2 grams IV should be administered