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# Attapulgite ## Overview Attapulgite is an adsorbent used for the symptomatic treatment of diarrhea. It works by absorbing excess water and toxins in the gastrointestinal tract. ## Primary Indications Symptomatic treatment of acute diarrhea. ## Adult Dosing * **Suspension:** 7.5 mL to 15 mL after each bowel movement, not to exceed 10 doses (75 mL) in 24 hours. * **Tablets:** 2 tablets (1 g) after each bowel movement, not to exceed 10 tablets (5 g) in 24 hours. ## Pediatric Dosing * **Children 3-6 years:** 7.5 mL of suspension after each bowel movement. Not to exceed 5 doses (37.5 mL) in 24 hours. * **Children 6-12 years:** 15 mL of suspension after each bowel movement. Not to exceed 5 doses (75 mL) in 24 hours. * **Children 3-6 years:** 1 tablet (500 mg) after each bowel movement. Not to exceed 5 tablets (2.5 g) in 24 hours. * **Children 6-12 years:** 2 tablets (1 g) after each bowel movement. Not to exceed 5 tablets (5 g) in 24 hours. * **Children <3 years:** Dosing not established. ## Dose Adjustments No specific dose adjustments are typically required for hepatic or renal impairment. However, caution should be exercised, especially in elderly patients or those with significant gastrointestinal motility issues. ## Contraindications * Known hypersensitivity to attapulgite. * Concurrent use with other medications, as it can impair their absorption. ## Adverse Effects Constipation is the most common adverse effect. Others may include abdominal discomfort or nausea. ## Key Drug Interactions Attapulgite can bind to and reduce the absorption of many oral medications. Administer other medications at least 2 hours before or 4-6 hours after attapulgite. ## Monitoring Monitor for relief of diarrhea symptoms. Monitor for signs of constipation. ## Clinical Pearls * Effectiveness is primarily symptomatic; does not treat the underlying cause of diarrhea. * Adequate fluid and electrolyte replacement is crucial when treating diarrhea. * Discontinue if diarrhea persists for more than 48 hours or if fever, blood, or mucus in the stool is present. *** *Disclaimer: This information is intended for healthcare professionals. Always verify current prescribing information and consult with a qualified healthcare provider before making any treatment decisions.*